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Institut za biološka istraživanja „Siniša Stanković”
Institut od nacionalnog značaja za Republiku Srbiju
Univerzitet u Beogradu

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Naturally aged rats, characterized by persulfidation decline, provide an adequate translational preclinical model for BPH: A hypothesis

Benign prostatic hyperplasia (BPH) is a prevalent age-related disorder characterized by progressive prostate enlargement. Current preclinical models fail to replicate decline in persulfidation and chronic oxidative stress, inflammation, and cellular aging that drive human BPH pathology. We propose that a naturally aging rat model (middle to early old-aged) provides a superior alternative by mimicking BPH progression as a multifactorial...

Evolutionary rate of adaptive chromosomal inversions in Drosophila subobscura (Diptera: Drosophilidae) in response to global warming

In the face of global warming, insects can employ various survival strategies. One possibility is that natural selection favors genetic combinations that are adaptive to this environmental situation. In some species, chromosomal inversions allow a particular combination of genes to be transmitted intact across generations, provided it is adaptive. Drosophila subobscura could therefore be considered a model species, given its rich chromosomal inversion polymorphism and its relationship with climate change...

New achievements in tissue culture of the vegetable and medicinal brassica Diplotaxis tenuifolia (L.)...

Wild rocket (Diplotaxis tenuifolia (L.) DC) is widely cultivated as a vegetable crop known for its nutritional and medicinal benefits, but also for its value as an oil, pasture and beekeeping crop. Biotechnological approaches are essential to respond to the new challenges in breeding, as conventional breeding methods have proven insufficient for further improvements. The aim of this study was to develop a shoot regeneration and propagation protocol for D. tenuifolia and to investigate its metabolic profile...

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