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Institute for Biological Research "Siniša Stanković"
National Institute of the Republic of Serbia
University of Belgrade

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Cold-Associated Tissue-Specific Structural Remodelling: A Fractal Assessment of Biological Age

Aging is characterized by a progressive loss of physiological complexity. In order to elucidate differences in aging manifestations throughout various tissues/organs, we investigated structural remodeling in interscapular brown adipose tissue (iBAT), gonadal and retroperitoneal white adipose tissues (WATs), and the liver of rats (3-, 6-, and 24-month-old) housed at 22 ± 1°C. An additional cohort of 24-month-old rats housed at 4 ± 1°C from 6 to 24 months of age was used to assess...

Differences in the elemental profiles of two obligate ultramaficophytes from the Balkans: Balkana spergulifolia and Polygonum albanicum

Ultramafic soils pose an edaphic challenge to plants, acting as a strong selection factor promoting speciation and endemism. Two obligate ultramaficophytes—Balkana spergulifolia and Polygonum albanicum—were analyzed for elemental profiles (“elementomics”) and differences in response to ultramafic soils. The plant samples, along with associated rhizosphere soils, were collected from selected ultramafic areas in Serbia and analyzed for their elemental concentrations...

ERα-Independent Activity of Tamoxifen-Based Transition Metal Hybrids in Triple-Negative Breast Cancer Models In Vitro and In Vivo

Multiple studies have demonstrated that the conjugation of various metal cores to a modified tamoxifen vector amplifies its antitumor activity, rendering such engineered structures effective even in triple-negative breast cancer (TNBC), a tumor subtype traditionally considered irrelevant for endocrine therapy. With a focus on TNBC cell line, this study shows that hybrids with Pd- and Cu- in comparison to Pt-based counterparts exerted an advanced cytotoxic profile in terms of sustained...

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