Project team:
Dr. Đorđe Miljković, project leader
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade:
Gordana Timotijević
Collaborators:
Vladimir Badovinac
Frančeska Odoardi
Multiple sclerosis is inflammatory, autoimmune disease of the central nervous system (CNS). The immune response directed towards cells and structures of CNS tissue causes demyelinization and neurodegeneration, thus inducing various neurological deficits in patients. In majority of patients multiple sclerosis takes relapsing-remitting or chronic progressive course. Experimental autoimmune encephalomyelitis (EAE) induced in DA rats is a model of multiple sclerosis and shares numerous immunopathogenic features with the human disease. Still, there is a major difference in the clinical course, as EAE in DA rats is acute monophasic disease. DA rats completely recover from EAE and are highly resistant to further attempts of the disease induction. The main goal of this project is to identify cell populations and molecular mechanisms responsible for the recovery of DA rats from EAE and their resistance to EAE re-induction. Consequently, the obtained knowledge should be useful for improvement of multiple sclerosis therapy.
Dr. Đorđe Miljković, project leader
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade:
Gordana Timotijević
Collaborators:
Vladimir Badovinac
Frančeska Odoardi
Address
Bulevar despota Stefana 142
11108 Belgrade
Serbia
Contact
Telefon: +381 11 20 78 300
Fax: +381 11 27 61 433
Email: ibiss@ibiss.bg.ac.rs