Education
2001-2009 Ph.D., Molecular Biology and Physiology, Faculty of Biology, University of Belgrade
1998-2001 M.S., Molecular Biology and Physiology, Faculty of Biology, University of Belgrade
1992-1998 B.S., Molecular Biology and Physiology, Faculty of Biology, University of Belgrade
Employment
Department of Neurobiology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, Serbia
2016- Principal Research Fellow
2009-2016 Senior Research Associate
2001-2009 Research Assistant
1998-2001 Junior Research Assistant
Research field/area
Behavioral neurosciences (biological psychology); Neurobiology of behavior
Research interest
Pharmacological and social factors in neurodevelopment and neurodegenerative disorders
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Education
2010 BSc in Biology, Faculty of Sciences, University of Novi Sad
2017 PhD in Biology, Animal and Human Physiology, Faculty of Biology, University of Belgrade
Research Topics
Reproductive Endocrinology, Endocrinology, Neurobiology
Career
2011-2014 Junior Research Assistant, Laboratory for Reproductive Endocrinology, Faculty of Sciences, University of Novi Sad
2014-2018 Teaching Assistant, Animal Physiology, Faculty of Sciences, University of Novi Sad
2018-2019 Research Assistant, Laboratory for molecular neurobiology, Department of Neurobiology, Institute for Biological Research ”Sinisa Stankovic”, National Institute of the Republic of Serbia, University of Belgrade
2019- Research Associate, Laboratory of molecular neurobiology, Department of Neurobiology, Institute for Biological Research ”Sinisa Stankovic”, National Institute of the Republic of Serbia, University of Belgrade
Postdoctoral Fellowship
2019-2022 Section on Cellular Signaling,NICHD, National Institutes of Health, Bethesda, USA
The biology of ageing is focused on better understanding the molecular, cellular and physiological processes underlying the ageing process and the diseases associated with this process.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
RESEARCH FIELD
Multidrug resistance in cancer; Mechanisms of action of new antitumor agents with the potential to overcome multidrug resistance; Development of new cell models and assays for preclinical testing of antitumor agents
EDUCATION
2011-2018 PhD degree at the Faculty of Biology, University of Belgrade, Serbia
2004-2011 Undergraduate studies of Molecular Biology and Physiology; University of Belgrade, Faculty of Biology, Belgrade, Serbia
EMPLOYMENT HISTORY
2019-present Department of Neurobiology, Institute for Biological Research “Siniša Stanković” - National Institute of Republic of Serbia (Belgrade, Serbia)
2012-2019 Department of Molecular Biology, Institute for Biological Research “Siniša Stanković” - National Institute of Republic of Serbia (Belgrade, Serbia)
SCIENTIFIC PROJECTS AND COLLABORATIONS
• Team member on Project: The Program PRISMA - Biomimetic tumor engineering to enhance drug discovery (BioengineeredTumor), Science Fund of the Republic of Serbia (2024-2027)
• Team member on Project: The Program IDEAS - Functional diagnostics in non-small cell lung carcinoma – a new concept for the improvement of personalized therapy in Serbian patients (TargetedResponse), Science Fund of the Republic of Serbia (2022–2024)
• Team member on Project: 173020 “Signaling Molecules in Diabetes: Search for Potential Targets in Intrinsic Pathways for Prediction and Intervention in Diabetes” Ministry of Education, Science and Technological Development (MPNTR), Republic of Serbia (2012 – 2019)
• Member of COST Action CA17104: New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumors (STRATAGEM) (2018 – 2022)
PROFESSIONAL MEMBERSHIP
1. Member of the Federation of European Neuroscience Societies from 2023
2. Member of the Serbian Biological Society from 2022
2. Member of the Serbian Association for Cancer Research from 2020
3. Member of the European Association for Cancer Research from 2020
Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).
Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.
EDUCATION
2010-2019 - Ph.D. in Neuroscience, Faculty of Biology, University of Belgrade, Serbia, (2 years of maternity leave). Title: The effect of long-term dietary restriction on insulin signaling pathway in rat brain during aging.
2000-2009 - B.Sc. in Molecular Biology and Physiology (subfield: Molecular neurobiology), Faculty of Biology, University of Belgrade, Serbia (average grade 9.03/10)
RESEARCH INTEREST
My research field is grounded on the effects of different nutritional approaches such as dietary restriction and fermented food, on behavioral and molecular patterns during aging and on the relations between healthspan and nourishment for the brain. One of the prime ambitions of my research is to establish the optimal food intake as well as pattern of food intake for healthy brain aging. Up to now, I have revealed that the beneficial effect of dietary restriction is highly dependent on the time of its commencement and duration in one’s lifetime.
POSITIONS AND EMPLOYMENT
Employment:
2010 – to date: Institute for Biological Research “Sinisa Stankovic” (IBISS), National Institute of Republic of Serbia, University of Belgrade
Research or academic titles:
2020-present Research Associate
ACADEMIC & TEACHING EXPERIENCE
Ph.D. theses supervisor
2021-present: Title: The Effect of fermented cabbage brine on lipopolysaccharide-induced oxidative stress and inflammation in C57BL/6 mice. Anđela Vukojević, University of Belgrade/Faculty of Biology (mentor)
Teaching experience:
2021- to date Faculty of Biology, University of Belgrade:
Lecturer: Neuroscience graduate programs - Methods in Neurobiology (2021-present)
OTHER ACHIEVEMENTS
1. 2021-to date: Co-leader of WG3 in COST action Promoting Innovation of ferMENTed fOods (PIMENTO) CA20128, member of the Core Group of PIMENTO
2. 2023-to date Reviewer for: Biofactors (IF:6.438), Dose-Response (IF: 2.623), Mechanisms of Ageing and Development (IF:4.3)
3. Rapporteur for TEATIME Cost Action
MEMBERSHIP
1. Federation of European Neuroscience Society (FENS)
2. Serbian Neuroscience Society (SNS)
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
The biology of ageing is focused on better understanding the molecular, cellular and physiological processes underlying the ageing process and the diseases associated with this process.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
The biology of ageing is focused on better understanding the molecular, cellular and physiological processes underlying the ageing process and the diseases associated with this process.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Dr. Miodrag Dragoj graduated in 2013 from the Faculty of Biology at the University of Belgrade, specializing in Molecular Biology and Physiology. In the academic year 2013/2014, he enrolled in doctoral studies in Molecular Biology, focusing on the Molecular Biology of Eukaryotes, at the University of Belgrade - Faculty of Biology. He has been employed at the Neurobiology Department of the 'Siniša Stanković' Institute for Biological Research at the University of Belgrade since July 2014.
During his doctoral studies, he conducted scientific research through the project 'Identification of molecular markers for predicting tumor progression, response to therapy, and disease outcome' (III41031), funded by the Ministry of Education, Science, and Technological Development of the Republic of Serbia. He completed his doctoral thesis, titled 'Effects of CXCR4 receptor and focal adhesion kinase inhibition in invasion suppression and overcoming resistance in non-small cell lung cancer,' obtaining the title of Doctor of Biological Sciences on October 9, 2018. He received the 'Goran Ljubijankić' Foundation award for the best doctoral thesis in molecular biology defended in 2018 in Serbia.
After his PhD, he represented Serbia in two international interdisciplinary projects: 'Optimization of glioblastoma therapy' (funded by the American James S. McDonnell Foundation) and 'Development of thioredoxin reductase inhibitors as new anti-cancer agents' (ERA.Net RUS+ project).
Dr. Dragoj currently leads a project work package in the project from IDEJE program titled 'Functional diagnostics of non-small cell lung cancer - a new concept for improving personalized therapy in Serbia' (TargetedResponse) and in the PRIZMA program titled 'Biomimetic tumor engineering to enhance drug discovery' (BioengineeredTumor), both supported by the Science Fund of the Republic of Serbia.
Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.
Biotechnology is defined as the use of biological processes and systems (living organisms or their parts) to develop or modify different processes or products useful to humans and includes analysis of risks of its implementation (biosafety).
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).
Scopus Author ID: 8944418500
Summary:
Principal Research Fellow in the Laboratory for Molecular Neurobiology and Behavior, with more than twenty years of research experience in molecular neurobiology. Author/coauthor of more than 30 peer-reviewed publications. Mentor of PhD and MSc students.
Research Focus:
The main focus of Dr. Perovic's research is on the molecular mechanisms underlying brain plasticity during aging and in age-related neurodegenerative disorders, particularly in Alzheimer’s disease (AD). By combining various biochemical, molecular, and histological approaches, she extensively studied the role of synaptic plasticity, inflammation, gliosis, cholesterol metabolism, stress-related, and BDNF signaling in age-related neurodegenerative changes. Her long-term goal is to understand how these mechanisms can be altered by different environmental and pharmacological interventions and to implement this knowledge into the search for novel and/or more effective AD therapies.
Education:
• B.Sc. in Molecular Biology and Physiology, Faculty of Biology, University of Belgrade, 1998
• M.Sc. in Biological Sciences, Faculty of Biology, University of Belgrade, 2002
• Ph.D. in Biological Sciences, Faculty of Biology, University of Belgrade, 2011
Honors and Awards:
• Fellowships for Advanced Postgraduate Students, Ministry of Science, Technology and Innovation of the Republic of Serbia, 1999 - 2002
• German Academic Exchange Service (Deutscher Akademischer Austauschdienst - DAAD) short-term fellowship, 2008
• High ranking scientist (A1), Ministry of Science, Technology and Innovation of the Republic of Serbia, 2011 - 2024
• Best PhD Thesis in Molecular Biology Award in 2011 - Foundation ”Goran Ljubijankić”
Society memberships:
Serbian Neuroscience Society (SNS), FENS - Federation of European Neuroscience Societies, Serbian Society for Microscopy, European Microscopy Society, Serbian Biochemical Society, American Heart Association (AHA)
Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.
Biotechnology is defined as the use of biological processes and systems (living organisms or their parts) to develop or modify different processes or products useful to humans and includes analysis of risks of its implementation (biosafety).
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).
Research interest
Reproductive endocrinology, neuroendocrinology, neuroinflammation
Education
2005: BSc Biology, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Republic of Serbia.
2012: Ph.D. Biochemistry, Department of Chemistry, Biochemistry and Environmental Protection; Faculty of Sciences University of Novi Sad, Republic of Serbia.
Work experience
2006-2013: Junior research assistant, research assistant, teaching Assistant, Laboratory for Reproductive Endocrinology and Signaling, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Republic of Serbia.
2013-2017: Assistant professor, Laboratory for Reproductive Endocrinology and Signaling, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Republic of Serbia.
2017-present: Senior Research Associate, Department of neurobiology, Institute for Biological Research “Sinisa Stankovic”, National Institute of the Republic of Serbia, University of Belgrade, Republic of Serbia.
Education abroad
2014-2017: Visiting Fellow, National Institutes of Health (NIH), National Institute of Child Health and Human Development (NICHD), Section on Cellular Signaling, Bethesda, Maryland, USA. Grant: ZIA HD000195-22, “Signaling and secretion in neuroendocrine cells”, Intramural Research Projects, funded by NIH, USA.
2020-2021: Postdoctoral Fellow, Children's National Medical Center, Children's Research Institute, Center for genetic medicine research, Washington DC, USA. Grant: 5R21TR003166-02, “Systemic biomarkers of brain injury from hyperammonemia”, funded by NIH, USA.
Awards
2006 -2008: Scholarship holder of the Ministry of Science, Republic of Serbia
2009 IUBMB/FEBS: Young Scientist Forum participation grant, Shanghai, China
2010 FEBS: Young Scientist Forum participation grant, Gothenburg, Sweden
Memberships
Serbian Neuroscience Society (SNS), Federation of European Neuroscience Societies (FENS), The European Society of Endocrinology (ESE)
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
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