Anđela Vukojević, third year PhD student at the Department of Molecular Biology, Faculty of Biology, University of Belgrade, (study program: Molecular Biology, module: Physiology, submodule: Animal and Human Physiology). She completed her undergraduate studies at the Department of Biology, Faculty of Science and Mathematics, University of Niš and graduated in 2018. She continued her master's studies at the same institution and achieved an overall grade point average of 9.27 in 2020. After her master's studies, Anđela completed an internship in the microbiology department of the Medicus Universalis health center in Kruševac. In 2021, she started her doctoral studies and began employment at the Institute for Biological Research "Siniša Stanković". Her research focuses on investigating the effect of fermented foods on the central nervous system. Her dissertation, is entitled "Effect of pretreatment with sauerkraut brine of a defined composition on oxidative stress and inflammatory processes trough the action of lipopolysaccharide in mice". In addition to her academic activities, Anđela is actively involved in the scientific community as a member of societies, including the Society for Neuroscience of Serbia (DNS), the Federation of European Neuroscience Societies (FENS), the Serbian Society for Molecular Biology (MolBioS) and the European Cooperation in Science and Technology (COST). She is actively involved in the PIMENTO COST Action, Promoting Innovation of Fermented Foods (CA20128), in the E7 project “PIMENTO E7: The Effects of Lactobacillus sp and/or Bifidobacterium sp in Fermented Foods on Cognitive Health: A Systematic Review”. As part of the same project, she was also involved in the development and implementation of the Fermented Food Questionnaire (FFFQ). She was a participant of the joint FEBS/IUBMB advanced course “Molecular Targets for Antiaging Interventions” in Spetses, Greece, 2022, supported by COST Action ITC Conference Grant. She was awarded the "IUBMB Life Poster Award" at @FebsIUBMB2022 event.
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Andrea Novaković is a second-year PhD student at the Faculty of Biology, University of Belgrade. She is currently employed as a Research trainee at the Department of neurobiology at the Institute for biological research ,,Siniša Stanković", National Institute of the Republic of Serbia, University of Belgrade.
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Ana Stepanović holds a master’s degree in molecular biology, from Faculty of Biology, University of Belgrade. She was awarded for the best master thesis in molecular biology by the Foundation "Goran Ljubijankić." She is a fourth-year PhD student at the Faculty of Biology, specializing in physiology - Translational research in neurobiology and biomedicine. She started her doctoral studies in 2020. Her PhD thesis focuses on the development of new hybrid compounds of sclareol and doxorubicin and testing their anticancer properties under the mentorship of Dr. Milica Pešić. Part of the thesis results are submitted in national and PCT patent applications "Hybrid compounds of sclareol and doxorubicin, their synthesis and application“, Priority date: November 14th, 2022, PCT Application No: PCT/RS2023/000016. Additionally, Ana is a team member on two projects funded by the Science Fund of the Republic of Serbia, "PhotoSCLART" project: development of nature-inspired photoresponsive anticancer agents - sclareol and artemisinin derivatives in cancer multidrug-resistance models: a foundation for the theranostic approach" and "TargetedResponse" project: Functional diagnostics in non-small cell lung carcinoma—a new concept for the improvement of personalized therapy in Serbian patients. Ana is also a member of the IBISS project "Proof of Concept" "Innovative hybrid compounds of sclareol and doxorubicin as new antitumor strategy in glioblastoma therapy" (SCLarDOXInn) and team member of Serbian Academy of Sciences (SANU) project entitled "Biomedical potential of newly isolated diterpenes of milk thistle latex in Serbia". She was a member of the Organizing Committee in the sixth congress of SDIR, "From Collaboration to Innovation in Cancer Research" in 2023, and COST Action CA17104, "New diagnostic and therapeutic tools against multidrug-resistant tumors" in 2020. Ana is a member of the Serbian Society of Cancer Researchers, the European Association of Cancer Research, the Society for Neuroscience of Serbia, and the Federation of European Neuroscience Societies.
Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Education:
Doctoral academic studies, Faculty of Biology, University of Belgrade; 2022
Master's academic studies, Faculty of Biology, University of Belgrade; 2022
Undergraduate academic studies, Faculty of Biology, University of Belgrade; 2021
Research Experience:
2022 – Preparation of doctoral thesis, Department of Molecular Biology, Institute for Biological Research "Siniša Stanković."
2021-2022 – Preparation of master's thesis, Department of Plant Physiology, Institute for Biological Research "Siniša Stanković."
Research Area:
Utilization of various constructs based on the CRISPR/dCas system aiming at silencing the Aristaless-related homeobox gene (ARX) and production of insulin-secreting cells.
Membership in Scientific Societies:
Member of the Serbian Society for Molecular Biology.
Participant in the science promotion event "Researchers' Night 2023."
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.
Physiology and molecular biology of plants studies the mechanisms underlying plant growth and development, plant morphogenesis in vitro (organogenesis, somatic embryogenesis, androgenesis), synthesis and accumulation of specialised metabolites, plant responses to different types of stressors, as well as allelopathic relationships between plants.
Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.
EDUCATION
2006 - PhD in Biological Sciences, Faculty of Biology (FB), University of Belgrade (UB)
2000 - MSc in Biological Sciences, FB, UB
1997 - BSc in Molecular Biology and Physiology, FB, UB
RESEARCH EXPERIENCE
2017 - Principal Research Fellow, Department of Molecular Biology (DMB), IBISS, UB
2012 - 2017 - Senior Research Associate, DMB, IBISS, UB
2007 - 2012 - Research Associate, DMB, IBISS, UB
2001 - 2007 - Research Assistant, DMB, IBISS, UB
1998 - 2000 - Scholarship, Ministry of Science and Technology, Republic of Serbia (RS)
RESEARCH INTEREST
Natural substances as potential supplements/therapeutics for the prevention and treatment of diabetes and its complications; Epigenetic regulation of gene expression and targeted methylation of particular gene loci - mechanisms of DNA methylation/demethylation and their functional relationship to altered signaling pathways in diabetes and cancer pathogenesis; Nutriepigenetics and nutriepigenomics.
PROJECTS
National:
2020- IBISS work program (No. 451-03-66/2024-03/200007), Ministry of Education, Technological Development and Innovation, RS
2011 - 2019 - OI173020, Ministry of Research and Technological Development, RS
2006 - 2010 - #143002B, Ministry of Science and Environmental Protection, RS
2002 - 2006 - #1722, Ministry of Science, Technology and Development, RS
International:
2024 - 2027 - Project: Strengthening Translational Research for Improved Metabolic Health (STRIMHealth) (Twining call HORIZON-WIDERA-2023, HORIZON EUROPE, European Commission)
2014 - 2019 - Project: Managing the effects of multiple stressors on aquatic ecosystems under water scarcity (Globaqua) (European Commission 7th Framework Programme Funding; No. 603629-ENV-2013-6.2.1)
2011 - 2024 - Participant in 5 COST Actions (TD0905, FA1201, CA16112 (MC member), CA15219 (MC substitute), CA21113).
SCIENTIFIC SOCIETIES
- Serbian Society for Molecular Biology - Vice president of the Governing Board
- Serbian Biochemical Society - member of the Advanced Courses Committee
- Serbian Proteomic Association - member of Governing Board (2015 - 2019); founding Council
- Serbian Biological Society
Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.
Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).
Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.
Education:
• 1998 B.Sc., Faculty of Biology, University of Belgrade, Department of Molecular Biology and Physiology: Average grade: 9.36/10
• 2002 M.Sc., Faculty of Biology, University of Belgrade
• 2007 Ph.D., Faculty of Biology, University of Belgrade
Research title:
• 2002: Research Assistant
• 2008: Research Associate
• 2013: Senior Research Associate
• 2020: Principal Research Fellow
Research interest:
• Diabetes (T1D and T2D) including pathophysiological mechanisms underlying the onset of diabetes and diabetic complications; Epigenetic changes, especially changes in DNA methylation/demethylation and their impact on the expression of genes relevant for the development of diabetes, fibroproliferative diseases and cancer. Novel research is directed towards targeted methylation of certain gene loci with the aim of changing the phenotype of cells.
Participation in projects:
• National projects: The IBISS work program financed by the Ministry of Education, Technological Development and Innovation, Republic of Serbia (2020-), contract number 451-03-66/2024-03/ 200007; OI173020 of the Ministry of Research and Technological Development, Republic of Serbia (2011 - 2019); #143002B of the Ministry of Science and Environmental Protection, Republic of Serbia (2006 - 2010); #1722 of the Ministry of Science, Technology and Development, Republic of Serbia (2002 – 2006).
• International projects and collaborations: Project of 7th Framework Programme of European Commission „Managing the effects of multiple stressors on aquatic ecosystems under water scarcity“ No. 603629-ENV-2013-6.2.1-Globaqua (2014 - 2019); Participation and coordination of international cooperation with Dr. Ludwig Wagner, Medical University of Vienna, Austria; dr. Talin Barisani-Asenbauer, Center for Pathophysiology, Infectiology & Immunology, Vienna, Austria; dr. Tomasz Jurkowski, Institute for Biochemistry, University of Stuttgart, Germany; COST actions: TD0905 (2010-2014), CA15219 (2016-2020), CA16119 (2017-2021).
Memberships in scientific societies:
• Serbian Society for Molecular Biology
• Serbian Biochemical Society – Member of the Fellowships Committee (2014 – 2017); Member of the Scientific Committee for the Serbian Biochemical Society Conferences (III – VII)
• Serbian Proteomic Association (SePA)
• Serbian Biological Society
Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.
Ecotoxicology studeies the toxic effects of chemicals on the environment. The effects are studied at the level of molecules, cells, tissues, organs, individual organisms, populations or ecosystems.
Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.
Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).
Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.
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