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Institute for Biological Research "Siniša Stanković"
National Institute of the Republic of Serbia
University of Belgrade

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Assessment of the Type and Degree of Genomic Instability in Gliomas

Glial brain tumours, including astrocytoma IDH (Isocitrate Dehydrogenase) mutant and glioblastoma IDH wild-type, are highly malignant brain tumours with poor clinical outcomes. Genomic instability, encompassing microsatellite (MIN) and chromosomal instability (CIN), drives tumour heterogeneity and evolution. In this study, genomic instability was analysed in 85 patients using AP-PCR (Arbitrarily Primed Polymerase Chain Reaction) by comparing tumour and normal tissue (blood) DNA profiles of the same patient. Both types of alterations were...

nido-carborane conjugates with ibuprofen, flurbiprofen and fenoprofen: synthesis, characterization, COX inhibition potential...

The search for novel anticancer drugs with reduced side effects and innovative therapeutic approaches remains a significant challenge. Non-steroidal anti-inflammatory drugs (NSAIDs), known to inhibit cyclooxygenase (COX) – an enzyme overexpressed in certain tumors – offer a promising avenue for cancer therapy. Additionally, icosahedral carboranes are emerging as a class of compounds with significant potential in drug design. Combining these two moieties into a single molecule...

Changes in Adaptive Immunity in Autoimmune Diseases and Aging: Shared Features, Key Differences, and Implications for...

Immunologically vulnerable populations (IVP) are particularly at risk of infection due to dysregulated immune responses. Parallels, as well as contrasts, have been drawn between IVP with autoimmune diseases (AI DIS) and older adults, the two by far most numerous IVP, related to their adaptive immune responses. Moreover, beyond the similarities and differences between these two groups, there is accumulating evidence that immune aging can drive certain aspects of autoimmunity...

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