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Institut za biološka istraživanja „Siniša Stanković”
Institut od nacionalnog značaja za Republiku Srbiju
Univerzitet u Beogradu

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Dissociation between gut microbiota remodeling and early gut-liver injury in CLP-induced sepsis

Introduction: Sepsis is a life-threatening condition in which early host responses critically determine organ dysfunction, yet strategies targeting this critical window remain limited. We investigated whether pre-septic modulation of host metabolism and gut microbiota could mitigate early organ injury in severe polymicrobial sepsis. Methods: Male Sprague-Dawley rats were pretreated for 4 weeks and then subjected to cecal ligation and perforation (CLP). Outcomes were assessed within the first 24 h after sepsis induction...

Salicylic Acid-Induced Elicitation of Nepetalactone and Rosmarinic Acid Biosynthesis in Naked Catmint (Nepeta nuda L.)...

Salicylic acid (SA) is involved in plant defense responses to environmental stressors by modulating gene expression and specialized metabolites production, enhancing plant adaptive resilience through systemic signalling pathways. This study investigates the impact of exogenous application of SA on the metabolism of iridoids and phenolic compounds—characteristic specialized metabolites of the Nepeta species, associated with diverse biological activities...

Sustainable cellulose acetate beads impregnated with eugenol, thymol, β-citronellol, and their mixtures via supercritical carbon...

Post-harvest losses of legumes caused by microbial contamination and pest insects represent a major challenge for food security and sustainable storage systems. In this study, biodegradable and bio-based cellulose acetate beads (CAB) were developed as functional materials for bean protection using an environmentally benign supercritical impregnation process. Eugenol, thymol, β-citronellol, and their mixtures were incorporated into CAB, achieving loadings of up to 7.5 wt% within a 3 h process...

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