EFSD - European Foundation for the Study of Diabetes: "Transdifferentiation of pancreatic alpha to beta cells via targeted epigenome editing using epi-crisprs directed dna methylation"

Goal: The current research project is focused on applying a novel synthetic epigenetic tool (Epi-CRISPRs) for straightforward, one-step pancreatic alpha to beta cell transdifferentiation by targeted DNA methylation and suppression of genes essential for maintaining pancreatic cell identity (homeobox genes Arx and Pax4).
The obtained results will be valuable for later Epi-CRISPRs use in mouse in vivo models of diabetes and eventually as a future therapy for diabetes attenuation in humans.

Period: 2015-2016

Dr. Melita Vidaković


Bulevar despota Stefana 142
11060 Beograd


Telefon: +381 11 20 78 300
Fax: +381 11 27 61 433
Email: ibiss@ibiss.bg.ac.rs

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