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Institut za biološka istraživanja „Siniša Stanković”
Institut od nacionalnog značaja za Republiku Srbiju
Univerzitet u Beogradu

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Najnovije publikacije

Cancer 3D Models: Essential Tools for Understanding and Overcoming Drug Resistance

Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies. Conventional two-dimensional (2D) cell cultures cannot replicate the complexity of the in vivo tumor microenvironment (TME), limiting their utility for drug resistance research. Therefore, three-dimensional (3D) tumor models have proven to be a promising alternative for investigating chemoresistance mechanisms. In this review, various cancer 3D models, including spheroids, organoids, scaffold-based models...

ADHD-like behaviors in adolescent mice prenatally exposed to levetiracetam: No safe gestational dose across sexes

Administering medication during pregnancy is always a challenging task. Levetiracetam (LEV), a second-generation antiepileptic drug, has been recognized as relatively safe based on studies assessing neurodevelopmental outcomes of children exposed to it in utero, despite some animal research reporting skeletal abnormalities. The potential link between intrauterine exposure to subtherapeutic or therapeutic doses of LEV and behavioral abnormalities in adolescent offspring has not yet been examined...

Soil eDNA-based droplet digital PCR assay as a new monitoring tool for terrestrial mammals

This study demonstrates the effectiveness of droplet digital PCR (ddPCR) for identifying vertebrate taxa from soil-derived environmental DNA (eDNA) – a methodological combination not previously documented in literature. The protocol is optimized for detecting cryptic species of the lesser blind mole rat (BMR). A total of 38 soil samples were collected from five cryptic BMR species across 12 localities in Serbia. Species-specific primer/probe sets were designed based on the cytochrome b (cytb) gene. After optimization of ddPCR assays...

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