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Institut za biološka istraživanja „Siniša Stanković”
Institut od nacionalnog značaja za Republiku Srbiju
Univerzitet u Beogradu

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Novel Ruthenacarborane–NSAID Conjugates

The significant side effects associated with platinum-based anticancer agents have driven the continuous pursuit of novel, non-platinum-based metal compounds. Ruthenium-based organometallic compounds have emerged as promising alternatives, owing to their distinctive and adaptable biochemical properties. The research efforts are focused on the development of ruthenacarborane-based anticancer drugs. The combination of ruthenium(II) complexes, recognized for their inherent anticancer potential, with carboranes...

Male Rat Model of Chemical Androgen Deprivation and Estrogenization from the Perspective of Anthropometric, Histological, and Biochemical...

Background and Objectives: Chemical androgen deprivation and estrogenization are essential components of clinical treatment for advanced prostate cancer and male-to-female sex transition. The aim of this study was to determine the effects of these therapies on anthropometric parameters, liver histology, and biochemical parameters, with the goal of establishing experimental models that accurately represent current clinical practice. Materials and Methods: Young adult Wistar rats were divided into nine...

Unlocking Demography: Developing an eDNA-Based Toolkitto Measure Sex Ratios From Populations

Demographic information, such as sex ratios, is essential for understanding population dynamics and informing conservationstrategies. Yet obtaining sex ratios in natural populations can be challenging due to logistical, ethical and legal constraints.Environmental DNA (eDNA) has revolutionised non-invasive biodiversity monitoring, but its potential for assessing demographicparameters remains largely unexplored. Here we present an eDNA-based method to monitor sex ratios...

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