Odabrane publikacije - Uticaj magnetnih polja i drugih sredinskih stresora na fiziološke odgovore i ponašanje različitih vrsta

1. Spasić S, Kesić S, Stojadinović G, Peković B, Todorović D (2015): Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis. Comp Biochem Physiol A Mol Integr Physiol 181:27-35.
2. Vlahović M, Ilijin L, Lazarević J, Mrdaković M, Gavrilović A, Matić D, Perić-Mataruga V (2014): Cadmium-induced changes of gypsy moth larval mass and protease activity. Comp Biochem Physiol C Toxicol Pharmacol 160:9-14.
3. Nikolić L, Bataveljić D, Andjus PR, Moldovan I, Nedeljković M, Petković B (2014): Modification of glial response in hibernation: a patch-clamp study on glial cells acutely isolated from hibernating land snail. J Biol Rhythms 29(6):442-455.
4. Ilijin L, Vlahović M, Mrdaković M, Mirčić D, Todorović D, Lazarević J, Perić-Mataruga V (2014): Responses of PTTH-producing neurosecretory neurons in Lymantria dispar caterpillars exposed to cadmium. Environ Toxicol 29(7):770-779.
5. Perić-Mataruga V, Vlahović M, Mrdaković M, Todorović D, Matić D, Gavrilović A, Ilijin L (2014): Prothoracicotropic hormone-producing neurosecretory neurons and antioxidative defense in midgut of Lymantria dispar in trophic stress. Tur J Biol 38(3):403-411.
6. Kesić S, Nikolić Lj, Savić A, Janać B, Spasić S (2014): Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension. Gen Physiol Biophys 33(3):335-344.
7. Mrdaković M, Stojković B, Perić-Mataruga V, Ilijin L, Vlahović M, Lazarević J (2014): Adaptive phenotypic plasticity of gypsy moth digestive enzymes. Cent Eur J Biol 9(3):309-319.
8. Todorović D, Marković T, Prolić Z, Mihajlović S, Rauš S, Nikolić L, Janać B (2013): The influence of static magnetic field (50 mT) on development and motor behaviour of Tenebrio (Insecta, Coleoptera). Int J Radiat Biol 89(1):44-50.
9. Vlahović M, Perić Mataruga V, Mrdaković M, Matić D, Lazarević J, Nenadović V, Ilijin L (2013): Enzymatic biomarkers as indicators of dietary cadmium in gypsy moth caterpillars. Environ Sci Pollut Res 20(5):3447-3455.
10. Selaković V, Rauš Balind S, Radenović L, Prolić Z, Janać B (2013): Age-dependent effects of ELF-MF on oxidative stress in the brain of Mongolian gerbils. Cell Biochem Biophys 66(3):513-521.
11. Nikolić L, Bataveljić D, Andjus PR, Nedeljković M, Todorović D, Janać B (2013): Changes in the expression and current of the Na+/K+ pump in the snail nervous system after exposure to a static magnetic field. J Exp Biol 216(18):3531-3541.
12. Mirčić D, Blagojević D, Perić-Mataruga V, Ilijin L, Mrdaković M, Vlahović M, Lazarević J (2013): Cadmium effects on the fitness-related traits and antioxidative defense of Lymantria dispar L. larvae. Environ Sci Pollut Res 20(1):209-218.
13. Rauš S, Selaković V, Manojlović-Stojanoski M, Radenović L, Prolić Z, Janać B (2013): Response of hippocampal neurons and glial cells to alternating magnetic field in gerbils submitted to global cerebral ischemia. Neurotox Res 23(1):79-91.
14. Mrdaković M, Perić-Mataruga V, Ilijin L, Vlahović M, Janković-Tomanić M, Mirčić D, Lazarević J (2013): Response of Lymantria dispar (Lepidoptera: Lymantriidae) larvae from differently adapted populations to allelochemical stress: Effects of tannic acid. Eur J Entomol 110(1):55-63.
15. Janać B, Selaković V, Rauš S, Radenović L, Zrnić M, Prolić Z (2012): Temporal patterns of extremely low frequency magnetic field-induced motor behavior changes in Mongolian gerbils of different age. Int J Radiat Biol 88(4):359-366.
16. Todorović D, Mirčić D, Ilijin L, Mrdaković M, Vlahović M, Prolić Z, Perić-Mataruga V (2012): Effect of magnetic fields on antioxidative defense and fitness-related traits of Baculum extradentatum (Insecta, Phasmatodea). Bioelectromagnetics 33(3):265-273.
17. Rauš S, Selaković V, Radenović L, Prolić Z, Janać B (2012): Extremely low frequency magnetic field induced changes in motor behaviour of gerbils submitted to global cerebral ischemia. Behav Brain Res 228(2):241-246.
18. Perić-Mataruga V, Vlahović M, Janać B, Ilijin L, Janković-Tomanić M, Matić D, Mrdaković M (2012): Ghrelin effect on nutritional indices, midgut and fat body of Lymantria dispar L. (Lymantriidae). Peptides 37(1)׃55-62.
19. Janković-Tomanić M, Lazarević J (2012): Effects of temperature and dietary nitrogen on genetic variation and covariation in gypsy moth larval performance traits. Arch Biol Sci, Belgrade 64(3):1109-1116.
20. Ilijin L, Vlahović M, Mrdaković M, Mirčić D, Prolić Z, Lazarević J, Perić-Mataruga V (2011): The effects of acute exposure to magnetic fields on morphometric characteristics of bombyxin-producing neurosecretory neurons in gypsy moth caterpillars. Int J Radiat Biol 87(5):461-471.

Odabrane publikacije - Uloga autofagije u regulaciji smrti tumorskih ćelija

1. Zogovic N, Tovilovic-Kovacevic G, Misirkic-Marjanovic M, Vucicevic L, Janjetovic K, Harhaji-Trajkovic L, Trajkovic V. Coordinated activation of AMP-activated protein kinase, extracellular signal-regulated kinase, and autophagy regulates phorbol myristate acetate-induced differentiation of SH-SY5Y neuroblastoma cells. J Neurochem. 2015;133(2):223–32.
2. Ristic B, Bosnjak M, Arsikin K, Mircic A, Suzin-Zivkovic V, Bogdanovic A, Perovic V, Martinovic T, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V, Harhaji-Trajkovic L. Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells. Exp Cell Res. 2014;326(1):90-102.
3. Bosnjak M, Ristic B, Arsikin K, Mircic A, Suzin-Zivkovic V, Perovic V, Bogdanovic A, Paunovic V, Markovic I, Bumbasirevic V, Trajkovic V, Harhaji-Trajkovic L. Inhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic death. PLoS One. 2014;9(4):e94374.
4. Tovilovic G, Zogovic N, Soskic V, Schrattenholz A, Kostic-Rajacic S, Misirkic-Marjanovic M, Janjetovic K, Vucicevic L, Arsikin K, Harhaji-Trajkovic L, Trajkovic V. Arylpiperazine-mediated activation of Akt protects SH-SY5Y neuroblastoma cells from 6-hydroxydopamine-induced apoptotic and autophagic death. Neuropharmacology. 2013;72:224-35.
5. Pantovic A, Krstic A, Janjetovic K, Kocic J, Harhaji-Trajkovic L, Bugarski D, Trajkovic V. Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells. Bone. 2013;52(1):524-31.
6. Harhaji-Trajkovic L, Arsikin K, Kravic-Stevovic T, Petricevic S, Tovilovic G, Pantovic A, Zogovic N, Ristic B, Janjetovic K, Bumbasirevic V, Trajkovic V. Chloroquine-mediated lysosomal dysfunction enhances the anticancer effect of nutrient deprivation. Pharm Res. 2012;29(8):2249-63.
7. Tovilovic G, Zogovic N, Harhaji-Trajkovic L, Misirkic-Marjanovic M, Janjetovic K, Vucicevic L, Kostic-Rajacic S, Schrattenholz A, Isakovic A, Soskic V, Trajkovic V. Arylpiperazine dopamineric ligands protect neuroblastoma cells from nitric oxide (NO)-induced mitochondrial damage and apoptosis. ChemMedChem. 2012;7(3):495-508.
8. Janjetovic K, Harhaji-Trajkovic L, Misirkic-Marjanovic M, Vucicevic L, Stevanovic D, Zogovic N, Sumarac-Dumanovic M, Micic D, Trajkovic V. In vitro and in vivo anti-melanoma action of metformin. Eur J harmacol. 2011;668(3):373-82.
9. Janjetovic K, Vucicevic L, Misirkic M, Vilimanovich U, Tovilovic G, Zogovic N, Nikolic Z, Jovanovic S, Bumbasirevic V, Trajkovic V, Harhaji-Trajkovic L.. Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. Eur J Pharmacol. 2011;651(1-3):41-50.
10. Vucicevic L, Misirkic M, Janjetovic K, Vilimanovich U, Sudar E, Isenovic E, Prica M, Harhaji-Trajkovic L, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy. 2011;7(1):40-50.
11. Vucicevic L, Misirkic-Marjanovic M, Paunovic V, Kravic-Stevovic T, Martinovic T, Ciric D, Maric N, Petricevic S, Harhaji-Trajkovic L, Bumbasirevic V, Trajkovic V. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78.
12. Arsikin K, Kravic-Stevovic T, Jovanovic M, Ristic B, Tovilovic G, Zogovic N, Bumbasirevic V, Trajkovic V, Harhaji-Trajkovic L. Autophagy-dependent and independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells. Biochim Biophys Acta. 2012;1822(11):1826-36.
13. Pantic I, Harhaji-Trajkovic L, Pantovic A, Milosevic NT, Trajkovic V. Changes in fractal dimension and lacunarity as early markers of UV-induced apoptosis. J Theor Biol. 2012;303:87-92.

Odabrane publikacije - Neurološki razvoj kod prenatalne izloženosti ploda antiepileptičnoj terapiji 

1. Martać Lj, Podgorac J, Sekulić S. Evaluation of the neurotoxical effect of aluminium on the wistar rat. Arch Biol Sci. 2010;62:585-588.
2. Sekulić SR, Ilić Đ, Novakov-Mikić A. Polyhydramnios and bone development: an unexplored relationship. Med Hypothes. 2010;75:312-4.
3. Sekulić SR, Mikov A, Petrović Đ. Probability for breech presentation and its significance. J Mater Fet Neonat Med. 2010;23:1160-4.
4. Keković G, Ćulić M, Martać M, Stojadinović G, Čapo I, Lalošević D, Sekulić S. Fractal dimension values of cerebral and cerebellar activity in rats loaded with aluminium. Med Biol Eng Comput. 2010;48:671-9.
5. Martać Lj, Grbić G, Keković G, Podgorac J, Ćulić M, Sekulić S, Lalošević D, Čapo I. Spectral changes of brain activity in offsping of rats exposed to aluminium during gestation and lactation. Arch Biol Sci. 2010;62:9-13.
6. Sekulić S, Naumović N, Lukač D, Stefanović S, Mikov A, Sakač D, Kopitović A. Ultrasound assessment of the effect of fetal position on the supine to prone righting reflex in guinea pig fetus. Period Biol. 2010;112:97-104.
7. Keković G, Stojadinović G, Martać Lj, Podgorac J, Sekulić S, Culić M. Spectral and Fractal Measures of Cerebellar and Cerebral Activity in Various Types of Anaesthesia. Acta Neurobiol Exp. 2010;70:67-75.
8. Sekulić S, Lukač D, Drapšin M, SuknjajaV, Keković G, Grbić G, Martać Lj. The righting reflex from a supine to a prone position in the guinea pig fetus. Gen Physiol Biophys. 2009;28:284-8.
9. Ćulić M, Keković G, Grbić G, Martać Lj, Soković K, Podgorac J, Sekulić S. Wavelet and Fractal Analysis of Rat Brain Activity in Seizures Evoked by Camphor Essential Oil and 1, 8-Cineole. Gen Physiol Biophis. 2009;28:33-40.
10. Sekulić SR, Žarkov M, Slankamenac P, Božić K, Vejnović T, Novakov-Mikić A. Decreased Expression of the Righting Reflex and Locomotor Movements in Breech-Presenting Newborns in the First Days of Life. Early Hum Develop. 2009;85:263-6.
11. Sekulić SR, Lukač D, Drapšin M, Čapo I, Lalošević D, Novakov-Mikić A. Ultrasonographic observation of maturation of basic movements in guinea pig fetuses. Cent Eur J Biol. 2009;4:58-61.
12. Spasić S, Ćulić M, Grbić G, Martać Lj, Sekulić S, Mutavdžić D. Spectral and fractal analysis of cerebellar activity after single and repeated brain njury. Bull Math Biol. 2008;70:1235-49.
13. Sekulic SR, Lalosevic D, Naumovic N, Putic S, Culic M. The probability for anterior and posterior presentation during the second half of gestation and at delivery among albino mice. Biologia (Bratislava). 2007;62:622-5.
14. Sekulic SR, Petrovic Đ, Runic R, Williams M, Vejnovic T. Does more than 50% of breech presentation exist? Twin Res Hum Genet 2007; 10: 649-54.
15. Sekulic SR, Bozic K, Bozic A, Borota J, Milka C. Precocial rodents as a new experimental model to study the effects of altered gravitational condition on fetal development. Micro Sci Tech. 2006;18:223-5.
16. Grbić GM, Ćulić M, Martać Lj, Soković MD, Spasić SZ, Djoković DD Effect Of Camphor Essential Oil On Rat Cerebral Cortex Activity As Manifested By Fractal Dimension Changes. Arch Biol Sci. 2008;60:547-53.
17. Culić M, Stojadinović G, Martać Lj, Soković MD . Use of the Hurst Exponent for Analysis of Electrocortical Epileptiform Activity Induced in Rats by Administration of Camphor Essential Oil or 1,8-Cineole. Neurophysiology. 2010;42:57-62.

Tokom procesa razvoja novih istraživačkih pravaca u Institutu, ranih 60-tih godina prošlog veka formirano je Odeljenje za kriofiziologiju pod rukovodstvom akademika prof. dr Radoslava Anđusa. Kasnije, zahvaljujući dr Miri Pašić, profesoru Biološkog fakulteta, osnovano je Odeljenje za neurofiziologiju, čiji je osnovni cilj bio ispitivanje neurofizioloških osnova ponašanja na ćelijskom nivou.

Primenom klasičnih elektrofizioloških tehnika (current clamp i voltage clamp), saradnici Odeljenja pod rukovodstvom dr Gordane Kartelije značajno su doprineli utvrđivanju osnovnih biofizičkih karakteristika pojedinačnih neurona vinogradskog puža Helix pomatia. Ova istraživanja su bila polazna osnova za dalju analizu funkcionalnih osobina neurona pod uticajem različitih aktivnih supstanci i faktora sredine (temperatura, svetlost, magnetna polja,...) i mehanizama neuromodulacije.

Pored klasičnih elektrofizioloških istraživanja na ganglijskom kompleksu puža, poslednjih godina primenom modernih tehnika analiziraju se i biofizičke osobine nervnih ćelija kičmenjaka. Metodom nametnute voltaže na deliću membrane (patch clamp) ispituju se jonske struje na nivou cele ćelije, kao i osobine pojedinačnih jonskih kanala nervnih ćelija u kulturi.

Elektrofiziološki signali analiziraju se primenom linearnih i nelinearnih matematičkih metoda (analiza talasića, fraktalna analiza), kao i razvijenih statističkih metoda (analiza nezavisnih komponenata). Primena pomenutih metoda omogućava detaljnu analizu aktivnosti pojedinačnih neurona i populacija neurona.

Delatnost Odeljenja je proširena na ispitivanje morfo-funkcionalnih karakteristika mozga i ponašanja eksperimentalnih životinja. Ispituju se efekti različitih neuroaktivnih supstanci, magnetnih polja i procesa starenja u fiziološkim i patofiziološkim stanjima. Nervne i glijalne ćelije se analiziraju metodom imunohistohemijskog obeležavanja i prate se promene nekih biohemijskih parametara u mozgu. Ponašanje životinja u specifičnim testovima (open field, plus maze, Porsolt forced swim, object recognition, light/dark box,...) automatski se prati i analizira korišćenjem Any-maze softvera.

Akcenat se stavlja i na jasno definisane neurološke i psihijatrijske bolesti ljudi. Korišćenjem animalnih modela (hemijski izazvane konvulzije kojima se sagledava epilepsija i primena aluminijuma koji se povezuje sa etiologijom Alchajmerove bolesti) ispituju se patogenetski mehanizmi koji učestvuju u nastanku pomenutih poremećaja, kao i farmakološki aktivne materije kojima bi moglo da se deluje protektivno. Postavljeni ciljevi se prate na osnovu biohemijskih i imunohistohemijskih promena u pojedinim strukturama mozga i kliničkog ispoljavanja nastalih poremećaja.

OSNOVNE TEME:

Elektrofiziologija nervnih ćelija
Analiza elektrofizioloških signala
Morfo-funkcionalne karakteristike mozga
Ponašanje životinja
Neuroaktivne supstance
Magnetna polja
Animalni modeli

Neurobiologija spavanja u starenju i bolesti – elektroencefalografski markeri i modeliranje u proceni poremećaja #173022

1. Saponjic J, Cvorovic J, Radulovacki M, Carley DW. Serotonin and noradrenaline modulate respiratory pattern disturbance evoked by glutamate injection into the pedunculopontine tegmentum of anesthetized rats. Sleep. 2005;28:560-70.
2. Saponjic J, Radulovacki M, Carley DW. Modulation of respiratory pattern and upper airway muscle activity by the pedunculopontine tegmentum: Role of NMDA receptors. Sleep Breath. 2006;10:195-202.
3. Saponjic J, Radulovacki M, Carley DW. Monoaminergic system lesions increase post-sigh respiratory pattern disturbance during sleep in rats. Physiol Behav. 2007;90:1-10.
4. Bojic T, SaponjicJ, Radulovacki M, Carley DW, Kalauzi A. Monotone signal segments analysis as a novel method of breath detection and breath-to-breath interval analysis in rat. Respir Physiol Neurobiol. 2008;161:273-80.
5. Bjelobaba I, Saponjic J. High volume microinfusion suppresses local astrocyte response within nucleus basalis of rat. Arch Ital Biol. 2013;151:24-32.
6. Saponjic J, Petrovic J, Kalauzi A, Ciric J, Lazic K, Radulovacki M, Carley DW. Sleep-state related EEG amplitude distribution in the rat model of cortical cholinergic innervation disorder. Sleep Biol Rhythms. 2013;11(2):105-15.
7. Petrovic J, Ciric J, Lazic K, Kalauzi A, Saponjic J. Lesion of the pedunculopontine tegmental nucleus in rat augments cortical activation and disturbs sleep/wake state transitions structure. Exp Neurol. 2013;247:562-71.
8. Petrovic J, Lazic K, Ciric J, Kalauzi A, Saponjic J. Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat. Behav Brain Res. 2013;256:108-18.
9. Petrovic J, Lazic K, Kalauzi A, Saponjic J. REM sleep diversity following the pedunculopontine tegmental nucleus lesion in rat. Behav Brain Res. 2014;271:258–68.
10. Bataveljic D, Petrovic J, Lazic K, Saponjic J, Andjus P. Glial response in the rat models of functionally distinct cholinergic neuronal denervations. J Neurosci Res. 2015;93(2):244-52.
11. Ciric J, Lazic K, Petrovic J, Kalauzi A, Saponjic J. Aging induced cortical drive alterations during sleep in rats. Mech Ageing Dev. 2015;146-148C:12–22.
12. Lazic K, Petrovic J, Ciric J, Kalauzi a., Saponjic J. Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson’s disease neuropathology. Neuroscience. 2015;304:1–13.

Plastičnost mozga tokom starenja: uticaj dijetalne restrikcije i anestezije #173056

1. Tesic V, Perovic M, Lazic D, Kojic S, Smiljanic K, Ruzdijic S, Rakic L, Kanazir S. Long-term intermittent feeding restores impaired GR signaling in the hippocampus of aged rat. J Steroid Biochem Mol Biol. 2015;149C:43-52.
2. Smiljanic K, Pesic V, Mladenovic Djordjevic A, Pavkovic Z, Brkic M, Ruzdijic S, Kanazir S. Long-term dietary restriction differentially affects the expression of BDNF and its receptors in the cortex and hippocampus of middle-aged and aged male rats. Biogerontology. 2015;16:71-83.
3. Smiljanic K, Vanmierlo T, Mladenovic-Djordjevic A, Perovic M, Ivkovic S, Luetjohann D, Kanazir S. Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats. AGE. 2014;36(3):1303-14.
4. Milanović D, Pešić V, Popić J, Tanić N, Kanazir S, Jevtović-Todorović V, Ruždijić S. Propofol anesthesia induces proapoptotic tumor necrosis factor-α and pro-nerve growth factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain. J Neurosci Res. 2014;92(10):1362-73.
5. Mladenovic Djordjevic A, Perovic M, Smiljanic K, Todorovic S, Tesic V, Ruzdijic S, Kanazir S. The effects of dietary restriction and aging on amyloid precursor protein and presenilin-1 mRNA and protein expression in rat brain. Neuroreport. 2014;25(6):398-403.
6. Perovic M, Tesic V, Mladenovic Djordjevic A, Smiljanic K, Loncarevic-Vasiljkovic N, Ruzdijic S, Kanazir S. BDNF transcripts, proBDNF and proNGF, in the cortex and hippocampus throughout the life span of the rat. AGE. 2013;35(6):2057-70.
7. Smiljanic K, Vanmierlo T, Mladenovic Djordjevic A, Perovic M, Loncarevic-Vasiljkovic N, Tesic V, Rakic Lj, Ruzdijic S, Lutjohann D, Kanazir S. Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver. Lipids. 2013;48(11):1069-77.
8. Popic J, Pesic V, Milanovic D, Todorovic S, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. Propofol-induced changes in neurotrophic signaling in the developing nervous system in vivo. PLoS One. 2012;7(4):e34396.
9. Loncarevic-Vasiljkovic N, Pesic V, Todorovic S, Popic J, Smiljanic K, Milanovic D, Ruzdijic S, Kanazir S. Caloric restriction suppresses microglial activation and prevents neuroapoptosis following cortical injury in rats. PLoS One. 2012;7(5):e37215.
10. Milanovic D, Popic J, Pesic V, Loncarevic-Vasiljkovic N, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. Regional and temporal profiles of calpain and caspase-3 activities in postnatal rat brain following repeated propofol administration. Dev Neurosci. 2010;32(4):288-301.
11. Pesić V, Milanović D, Tanić N, Popić J, Kanazir S, Jevtović-Todorović V, Ruzdijić S. Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia. Int J Dev Neurosci. 2009;27(3):279-87

Ćelijska i molekulska osnova neuroinflamacije: potencijalni ciljna mesta za translacionu medicinu i terapiju #41014

1. Božić I, Savić D, Laketa D, Bjelobaba I, Milenković I, Peković S, Nedeljković N, Lavrnja I. Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia. PLoS One. 2015;10(2):e0118372.
2. Lavrnja I, Trifunovic S, Ajdzanovic V, Pekovic S, Bjelobaba I, Stojiljkovic M, Milosevic V. Sensorimotor cortex ablation induces time-dependent response of ACTH cells in adult rats: behavioral, immunohistomorphometric and hormonal study. Physiol Behav. 2014;125:30–7.
3. Lavrnja I, Ajdzanovic V, Trifunovic S, Savic D, Milosevic V, Stojiljkovic M, Pekovic S. Cortical ablation induces time-dependent changes in rat pituitary somatotrophs and upregulates growth hormone receptor expression in the injured cortex. J Neurosci Res. 2014;92(10):1338–49.
4. Lavrnja I, Laketa D, Savic D, Bozic I, Bjelobaba I, Pekovic S, Nedeljkovic N. Expression of a second ecto-5'-nucleotidase variant besides the usual protein in symptomatic phase of experimental autoimmune encephalomyelitis. J Mol Neurosci. 2015;55(4):898–911.
5. Savić D, Stojiljkovic M, Lavrnja I, Parabucki A, Bjelobaba I, Nedeljkovic N, Herdegen T, Pekovic S. Ribavirin shows immunomodulatory effects on activated microglia. Immunopharmacol Immunotoxicol. 2014;36(6):433–41.
6. Brkic P, Stojiljkovic M, Jovanovic T, Dacic S, Lavrnja I, Savic D, Parabucki A, Bjelobaba I, Rakic L, Pekovic S. Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats. Brain Injury. 2012. p. 1273–84.
7. Parabucki AB, Bozić ID, Bjelobaba IM, Lavrnja IC, Brkić PD, Jovanović TS, Savić DZ, Stojiljković MB, Peković SM. Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats. Croat Med J. 2012;53(6):586–97.
8. Lavrnja I, Savic D, Bjelobaba I, Dacic S, Bozic I, Parabucki A, Nedeljkovic N, Pekovic S, Rakic L, Stojiljkovic M. The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis. Journal of Pharmacological Sciences. 2012. p. 221–32.
9. Bjelobaba I, Lavrnja I, Parabucki A, Stojkov D, Stojiljkovic M, Pekovic S, Nedeljkovic N. The cortical stab injury induces beading of fibers expressing ecto-nucleoside triphosphate diphosphohydrolase 3. Neuroscience. 2010;170:107-16.
10. Laketa D, Bjelobaba I, Savic J, Lavrnja I, Stojiljkovic M, Rakic L, Nedeljkovic N. Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum. Mol Cell Biochem. 2010;339:99-106.
11. Lavrnja I, Stojkov D, Bjelobaba I, Pekovic S, Dacic S, Nedeljkovic N, Mostarica-Stojkovic M, Stosic-Grujicic S, Rakic L, Stojiljkovic M. Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production. Int Immunopharmacol. 2008;8:1282-90.
12. Stojkov D, Lavrnja I, Pekovic S, Dacic S, Bjelobaba I, Mostarica-Stojkovic M, Stosic-Grujicic S, Jovanovic S, Nedeljkovic N, Rakic L, Stojiljkovic M. Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: clinical and histopathological evaluation. J Neurol Sci. 2008;267:76-85
13. Nedeljkovic N, Bjelobaba I, Subasic S, Lavrnja I, Pekovic S, Stojkov D, Vjestica A, Rakic L, Stojiljkovic M. Up-regulation of ectonucleotidase activity after cortical stab injury in rats. Cell Biol Int. 2006;306:541-6.
14. Pekovic S, Subasic S, Nedeljkovic N, Bjelobaba I, Fillipovic R, Milenkovic I, Lavrnja I, Stojkov D, Jovanovic S, Rakic Lj, Stojiljkovic M. Molecular basis of brain injury and repair. In: Ruzdijic S, Rakic Lj, editors. Neurobiological studies – From genes to behavior. Keral: Research Signpost; 2006.p.143-65.
15. Peković S, Filipović R, Subasić S, Lavrnja I, Stojkov D, Nedeljković N, Rakić L, Stojiljković M. Downregulation of glial scarring after brain injury: the effect of purine nucleoside analogue ribavirin. Ann NY Acad Sci. 2005,1048:296-310

Identifikacija molekularnih markera za predikciju progresije tumora, odgovora na terapiju i ishoda bolesti #41031

1. Stojsic J, Stankovic T, Stojkovic S, Milinkovic V, Dinic J, Milosevic Z, Milovanovic Z, Tanic N, Bankovic J. Prolonged survival after neoadjuvant chemotherapy related with specific molecular alterations in the patients with nonsmall-cell lung carcinoma. Exp Mol Pathol. 2014;98(1):27-32.
2. Dinić J, Novaković M, Podolski-Renić A, Stojković S, Mandić B, Tešević V, Vajs V, Isaković A, Pešić M. Antioxidative activity of diarylheptanoids from the bark of black alder (Alnus glutinosa) and their interaction with anticancer drugs. Planta Med. 2014;80(13):1088-96.
3. Milosevic Z, Pesic M, Stankovic T, Dinic J, Milovanovic Z, Stojsic J, Dzodic R, Tanic N, Bankovic J. Targeting RAS/MAPK/ERK and PI3K/AKT/mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma. Transl Res. 2014;164(5):411-23.
4. Mori M, Vignaroli G, Cau Y, Dinić J, Hill R, Rossi M, Colecchia D, Pešić M, Link W, Chiariello M, Ottmann C, Botta M. Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693. ChemMedChem. 2014;9(5):973-83.
5. Stankovic T, Milinkovic V, Bankovic J, Dinic J, Tanic N, Dramicanin T, Tanic N. Comparative analyses of individual and multiple alterations of p53, PTEN and p16 in non-small cell lung carcinoma, glioma and breast carcinoma samples. Biomed Pharmacother. 2014;68(5):521-6.
6. Liu Q, Manzano D, Tanić N, Pesic M, Bankovic J, Pateraki I, Ricard L, Ferrer A, de Vos R, van de Krol S, Bouwmeester H. Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway. Metab Eng. 2014;23:145-53.
7. Novaković M, Pešić M, Trifunović S, Vučković I, Todorović N, Podolski-Renić A, Dinić J, Stojković S, Tešević V, Vajs V, Milosavljević S. Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells. Phytochemistry. 2014;97:46-54.
8. Milinkovic V, Bankovic J, Rakic M, Stankovic T, Skender-Gazibara M, Ruzdijic S, Tanic N. Identification of novel genetic alterations in samples of malignant glioma patients. PLoS One. 2013;8(12):e82108.
9. Podolski-Renic A, Jadranin M, Stankovic T, Bankovic J, Stojkovic S, Chiourea M, Aljancic I, Vajs V, Tesevic V, Ruzdijic S, Gagos S, Tanic N, Pesic M. Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. Cancer Chem Pharmacol. 2013;72(3):683-97.
10. Banković J, Andrä J, Todorović N, Podolski-Renić A, Milošević Z, Miljković D, Krause J, Ruždijić S, Tanić N, Pešić M. The elimination of P-glycoprotein over-expressing cancer cells by antimicrobial cationic peptide NK-2: the unique way of multi-drug resistance modulation. Exp Cell Res. 2013;319(7):1013-27.
11. Dačević M, Isaković A, Podolski-Renić A, Isaković AM, Stanković T, Milošević Z, Rakić Lj, Ruždijić S, Pešić M. Purine nucleoside analog - sulfinosine modulates diverse mechanisms of cancer progression in multi-drug resistant cancer cell lines. PLoS One. 2013;8(1):e54044.
12. Jadranin M, Pešić M, Aljančić IS, Milosavljević SM, Todorović NM, Podolski-Renić A, Banković J, Tanić N, Marković I, Vajs VE, Tešević VV. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. Phytochemistry. 2013;86:208-17.

Pet publikacija istraživača IBISS-a objavljeno u časopisu Drug Resistance Updates (IF = 18.5)

Tokom 2020. i 2021. godine saradnici Odeljenja za neurobiologiju Instituta za biološka istraživanja „Siniša Stanković" - Instituta od nacionalnog značaja za Republiku Srbiju (Laboratorija za molekularnu neuro-onkologiju) objavili su 5 publikacija u međunarodnom časopisu izuzetnih vrednosti (M21a) Drug Resistance Updates (IF = 18.5). Drug Resistance Updates je rangiran u Journal Citation Reports među prva 3 časopisa u svojoj oblasti nauka (Pharmacology & Pharmacy).

Publikacije se mogu pročitati na sledećim linkovima:

Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance

Repurposing old drugs to fight multidrug resistant cancers

What sustains the multidrug resistance phenotype beyond ABC efflux transporters? Looking beyond the tip of the iceberg

Advanced technological tools to study multidrug resistance in cancer

In vitro biomimetic models for glioblastoma-a promising tool for drug response studies

Rad istraživača IBISS-a među 15 izabranih radova časopisa Frontiers in Neuroscience

Rad kolega Odeljenja za neurobiologiju IBISS, publikovan u časopisu Frontiers in Neuroscience (IF 3.707) je izabran od strane glavnog editora prof. Luis de Lecea (Sleep and Circadian Rhythms Editor’s Pick 2021 collection) u 15 naučno-najkvalitetnijih radova za 2021.godinu: https://www.frontiersin.org/research-topics/21519/sleep-and-circadian-rhythms-editors-pick-2021

E-knjiga ovih 15 izabranih radova je trenutno u produkciji.

11. forumu Federacije evropskih društava za neuronauke u Berlinu

Saradnici Odeljenja za neurobiologiju IBISS, na 11-om forumu Federacije evropskih društava za neuronauke (Federation of European Neuroscience Societies-FENS) u Berlinu, jul 2018. godine. Naši saradnici su uživali u raznovrsnom programu najvećeg evropskog kongresa iz oblasti neuronauka i imali priliku da predstave svoja istraživanja.

Beograd će sledeće godine biti domaćin regionalnog kongresa pod pokroviteljstvom FENS, u organizaciji srpskog, turskog i rumunskog društva za neuronauke. Tako je FENS forum bio i prilika za sastanak organizacionog odbora FRM2019. Poziv za prijavu simpozijuma je otvoren! Više informacija možete naći na web stranici: www.fensfrm2019.rs

Poziv za predlaganje simpozijuma za FRM2019

Otvoren je poziv za predlaganje simpozijuma za Regionalni kongres FRM2019 koji će se odžati u Beogradu od 10-13. jula 2019. pod pokroviteljstvom Evropskog društva za neuronauke (FENS). Kongres organizuju Društva za neuronauke Srbije, Rumunije i Turske. Poziv je otvoren do 01.09.2018. Detaljnije informacije možete naći na sajtu Kongresa: www.fensfrm2019.rs/symposia/

COST Akcija CA17104 STRATAGEM

Dr Milica Pešić, dr Ana Podolski-Renić, dr Tijana Stanković, dr Jelena Dinić, dr Sonja Stojković Burić i Miodrag Dragoj učesnici su COST Akcije CA17104 STRATAGEM (Novi dijagnostički i terapeutski pristupi protiv višestruko rezistentnih tumora) koja se realizuje u periodu od 2018 do 2022, podržanoj od strane COST-a (Evropska Kooperacija u Nauci i Tehnologiji). Ko-predlagač Akcije i član Rukovodećeg komiteta (MC) je dr Milica Pešić, dok dr Ana Podolski-Renić vrši funkciju zamenika člana Rukovodećeg komiteta (MC substitute).

Predavanje dr Milice Pešić na godišnjem skupu Globalne Akademije Mladih u Pataji, Tajland

Na Osmom sastanku Međunarodne konferencije mladih naučnika i godišnjeg skupa Globalne Akademije Mladih (GYA) u Pataji, Tajland, 8. maja 2018 dr Milica Pešić je održala predavanje: "Detekcija i tretman rezistencije na lekove u kanceru". Dr Milica Pešić je lider GYA radnih grupa Biodiverzitet za preživljavanje putem biomedicine (Bio2Bio) i Žene u nauci (WiS).

Naslovna strana časopisa Histochemistry and Cell Biology 148(5)2017

Za naslovnu stranu časopisa Histochemistry and Cell Biology (Volume 148, Issue 5, November 2017) odabrana je slika iz rada: Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells, autora: Aleksandra Divac Rankov, Mila Ljujić, Marija Petrić, Dragica Radojković, Milica Pešić, Jelena Dinić.

Izveštaj sa Trećeg kongresa Srpskog društva istraživača raka

Na Trećem kongresu Srpskog društva istraživača raka, održanom od 6-7. oktobra
2017, naš Institut je bio suorganizator. Koleginice sa Odeljenja za neurobiologiju i Odeljenja za imunologiju su učestvovale u organizaciji i naučnom delu programa 7. oktobra 2017. Panel diskusija je vođena sa predavačima iz inostranstva (prof Ignacio Ochoa Garrido sa Univerziteta u Saragosi, Španija; prof Engin Ulukaya sa Istinje Univerziteta u Istanbulu, Turska; prof Konstantinos Dimas sa Univerziteta u Tesaliji, Grčka) i domaćim učesnicima sa IBISS-a (dr Milica Pešić, dr Tijana Stanković, dr Sanja Mijatović, dr Jelena Dinić i dr Ana Podolski-Renić).

Predavanje dr Milice Pešić na Četvrtom sastanku COST akcije CM1407 u Lisabonu

Na Četvrtom sastanku COST akcije CM1407 u Lisabonu, dr Milica Pešić je održala predavanje:
"Dvojni inhibitori u tretmanu kancera". Dr Milica Pešić je lider radne grupe za istraživanje kancera u okviru ove COST akcije.

Snimak predavanja je dostupan na sledećem linku: https://drive.google.com/file/d/0B0z9_MnrOvGESDJCOE45UjA4UTQ/view?usp=drive_web

Neuroscience 2015 (304) Naslovna strana

Slika 9 iz publikacije Lazic K., Petrovic J., Ciric J., Kalauzi A., Saponjic J. Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson disease neuropathology, Neuroscience, 2015, 304, 1-13, izabrana je za naslovnu stranu časopisa Neuroscience (304).

Nagrada Fondacije „Akademik Radoslav K. Anđus“ za 2013/2014. godinu

Dr Jelena Petrović je dobitnik nagrade Fondacije „Akademik Radoslav K. Anđus“ za najbolji rad iz oblasti fiziologije/biofizike za 2013/2014. godinu za publikaciju:

Petrovic Ј, Ciric Ј , Lazic К, Kalauzi А, Saponjic Ј. Lesion of the pedunculopontine tegmental nucleus in rat augments cortical activation and disturbs sleep/wake state transitions structure, Experimental Neurology, 2013, 247, 562-571.

Saradnja sa Laboratorijom za matematičku onkologiju, Univerzitet La Mancha, Špan

http://matematicas.uclm.es/imaci/molab/event/?idevento=213

Članstvo u Globalnoj akademiji mladih (GYA)

http://www.globalyoungacademy.net/

Aktivno učešće u COST Action CM1106 StemChem

http://www.stemchem.org/

Društvo za neuronauke Srbije (DNS)

www.srneurosoc.ac.rs

Saradnja sa kompanijom Selleckchem, SAD

https://www.dropbox.com/s/71p2i7ksz5nb3dk/Collaboration%20with%20Selleckchem.avi?dl=0

Projekat Centra za promociju nauke (2017-2018): Biomonitoring površinskih voda

Voda je od neprocenjive važnosti za opstanak života na planeti zato zahteva posebnu brigu. Biomonitoring rečnih tokova u lokalnim zajednicama omogućava bolјu kontrolu zagađenja i jačanje pokreta za očuvanje prirodnih resursa. Allium anafazno-telofazni test se koristi za procenu toksičnih i genotoksičnih efekata uzoraka voda ili hemikalija. Primenićemo ga da ispitamo efekte koje industrijska postrojenja i komunalne vode grada mogu imati na kvalitet rečne vode. Testiranje ćemo ponoviti u dva navrata, kako bismo utvrdili i efekte vodostaja na zagađenje reka. Pored procene stanja reka cilј nam je da obučimo učenike osnovnih i srednjih škola, kao i njihove nastavnike i profesore kako da samostalno sprovode ovaj tip testiranja. Na ovaj način želimo da doprinesemo jačanju ekološke svesti kod dece školskog uzrasta i pobolјšanju kvaliteta praktične nastave u školama.

Učesnici projekta:
dr Jelena Blagojević (rukovodilac projekta)
Ivana Budinski
Marija Rajičić
dr Vladimir Jovanović
dr Mladen Vujošević

Najbolja studentska poster prezentacija od kompanije Wildlife Acoustics

Na XIV Evropskom simpozijum za istraživanje slepih miševa (1 - 5. 8. 2017. u San Sebastijan, Baskija, Španija) Ivana Budinski dobila je nagradu za najbolju studentsku poster prezentaciju od kompanije Wildlife Acoustics. Pored diplome Ivana je dobila uređaj Echo Meter Touch Pro 2 i licencu za softver Kaleidoscope Pro.

1. Budinski I, Jojić V, Jovanović VM, Bjelić-Čabrilo O, Paunović M, Vujošević M. Cranial variation of the greater horseshoe bat Rhinolophus ferrumequinum (Chiroptera: Rhinolophidae) from the central Balkans. Zool Anzeiger - A J Comp Zool. 2015;254:8–14.
2. Rajičić M, Adnađević T, Stamenković G, Blagojević J, Vujošević M. Screening of B chromosomes for presence of two genes in yellow-necked mice, Apodemus flavicollis (Mammalia, Rodentia). Genetika. 2015;47(1):311-321.
3. Stamenković G, Nikolić V, Blagojević J, Bugarski-Stanojević V, Adnađević T, Stanojević M, Vujošević M. Genetic Analysis of Dobrava-Belgrade Virus from Western Serbia - A Newly Detected Focus in the Balkan Peninsula. Zoonoses Public Health. 2015;62(2):141–50.
4. Jojić V, Bugarski-Stanojević V, Blagojević J, Vujošević M. Discrimination of the sibling species Apodemus flavicollis and A. sylvaticus (Rodentia, Muridae). Zool Anzeiger - A J Comp Zool. 2014;253(4):261–9.
5. Adnađević T, Jovanović VM, Blagojević J, Budinski I, Cabrilo B, Bijelić-Čabrilo O, Vujošević M. Possible influence of B chromosomes on genes included in immune response and parasite burden in Apodemus flavicollis. PLoS One. 2014;9(11):e112260.
6. Čabrilo B, Jovanović VM, Bjelić-Čabrilo O, Budinski I, Blagojević J, Vujošević M. Diversity of nematodes in the yellow-necked field mouse Apodemus flavicollis from the Peripannonic region of Serbia. J Helminthol. 2014;1–7.
7. Blagojevic J, Jovanovic V, Adnadjevic T, Budinski I, Vujosevic M. Chromosome status of marsh marigold, Caltha palustrisL. (Ranunculaceae) from Serbia. Genetika. 2013;45(3):793–8.
8. Bugarski-Stanojević V, Blagojević J, Adnadević T, Jovanović V, Vujošević M. Identification of the sibling species Apodemus sylvaticus and Apodemus flavicollis (Rodentia, Muridae) - Comparison of molecular methods. Zool Anz. 2013;252(4):579–87.
9. Vujoševic M, Jovanović V, Blagojević J. Polyploidy and B chromosomes in Allium flavum from Serbia. Arch Biol Sci. 2013;65(1):23–32.
10. Adnadević T, Bugarski-Stanojević V, Blagojević J, Stamenković G, Vujošević M. Genetic differentiation in populations of the yellow-necked mouse, Apodemus flavicollis, harbouring B chromosomes in different frequencies. Popul Ecol. 2012;54(4):537–48.
11. Jojić V, Blagojević J, Vujošević M. Two-module organization of the mandible in the yellow-necked mouse: a comparison between two different morphometric approaches. J Evol Biol. 2012;25(12):2489–500.
12. Jojić V, Nenadović J, Blagojević J, Paunović M, Cvetković D, Vujošević M. Phenetic relationships among four Apodemus species (Rodentia, Muridae) inferred from skull variation. Zool Anzeiger - A J Comp Zool. 2012;251(1):26–37.
13. Blagojević J, Jovanović V, Stamenković G, Jojić V, Bugarski-Stanojević V, Adnadević T, Vujošević M. Age differences in bioaccumulation of heavy metals in populations of the black-striped field mouse, Apodemus agrarius (Rodentia, Mammalia). Int J Environ Res. 2012;6(4):1045–52.
14. Mašković P, Maksimović JD, Maksimović V, Blagojević J, Vujošević M, Manojlović NT, Radojković M, Cvijović M, Solujić S. Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dőrfler. Central European Journal of Biology. 2012. p. 327–33.
15. Jojić V, Blagojević J, Vujošević M. B chromosomes and cranial variability in yellow-necked field mice (Apodemus flavicollis). J Mammal. 2011;92(2):396–406.
16. Bugarski-Stanojević V, Blagojević J, Stamenković G, Adnađević T, Giagia-Athanasopoulou EB, Vujošević M. Comparative study of the phylogenetic structure in six Apodemus species (Mammalia, Rodentia) inferred from ISSR-PCR data. Syst Biodivers. 2011;9(1):95–106.
17. Milenković M, Jojić Šipetić V, Blagojević J, Tatović S, Vujošević M. Skull variation in Dinaric-Balkan and Carpathian grey wolf populations revealed by geometric morphometric approaches. J Mammal. 2010;91(2):376-86.
18. Blagojević J, Stamenković G, Vujošević M. Potential genotoxic effects of melted snow from an urban area revealed by theAllium cepa test. Chemosphere 2009;76:1344-7.
19. Blagojević J, Stamenković G, Jojić Šipetić V, Bugarski-Stanojević V, Adnađević T, Vujošević M. B chromosomes in populations of yellow-necked mice – stowaways or contributing genetic elements? Ital J Zool. 2009;76(3): 250–7.
20. Vujošević M, Blagojević J, Jojić-Šipetić V, Bugarski-Stanojević V, Adnađević T, Stamenković G. Distribution of B chromosomes in age categories of the yellow-necked mouse Apodemus flavicollis (Mammalia, Rodentia). Arch Biol Sci. 2009;61(4):653-8.
21. Bugarski-Stanojević V, Blagojević J, Adnađević T, Jojić V, Vujošević M. Molecular phylogeny and distribution of three Apodemus species (Muridae, Rodentia) in Serbia. J Zoolog Syst Evol Res. 2008;46(3):278-86.
22. Vujošević M, Anđelković S, Savić G, Blagojević J. Genotoxicity screening of the river Rasina in Serbia using the Alliumanaphase-telophase test. Environ Monit Assess. 2008;147(1-3):75-81.
23. Jojić V, Blagojević J, Ivanović A, Bugarski-Stanojević V, Vujošević M. Morphological integration of the mandible in yellow-necked field mouse: The effects of B chromosomes. J Mammal. 200788(3): 689-95.
24. Vujošević M, Jojić V, Bugarski-Stanojević V, Blagojević J. Habitat quality and B chromosomes in the yellow-necked mouseApodemus flavicollis. Ital J Zool. 2007;74(4):313-6.
25. Blagojević J, Jojić V, Bugarski-Stanojević V, Adnađević T, Vujošević M. Do B chromosomes affect fecundity in yellow-necked mouse Apodemus flavicollis (Rodentia, Mammalia)? Arch Biol Sci. 2006;58(4):221-3.
26. Vujošević M, Jojić V, Blagojević J. Intra individual variation in the number of B chromosomes in the yellow-necked mouseApodemus flavicollis (Rodentia, Mammalia). Folia Biol (Krakow). 2005;53(1-2):75-8.
27. Tanić N, Vujošević M, Dedović N, Dimitrijević B. Differential gene expression in yellow-necked mouse Apodemus flavicollis(Rodentia, Mammalia) with and without B chromosomes. Chromosoma, 2005;113:418-27.
28. Blagojević J, Vukićević-Radić O, Vujošević M. B chromosomes and asymetry of eye lenses in the yellow-necked mouseApodemus flavicollis (Rodentia, Mammalia). Belg J Zool. 2005;135(1):79-81.
29. Vujošević M, Blagojević J. Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo. Acta Vet Hung. 2004;52(4):439-43.
30. Vujošević M, Blagojević J. B chromosomes in populations of mammals. Cytogenet Genome Res. 2004;106:247-56.
31. Blagojević J, Vujošević M. B chromosomes and developmental homeostasis in the yellow-necked mouse, Apodemus flavicollis (Rodentia, Mammalia): Effects on nonmetric traits. Heredity. 2004;93:249-54.
32. Vujošević M, Blagojević J. Does environment affect polymorphism of B chromosomes in the yellow-necked mouseApodemus flavicollis? Z Saugetierkd. 2000;65:313-7.
33. Tanić N, Dedović N, Vujošević M, Dimitrijević B. DNA profiling of B-chromosomes from the yellow-necked mouseApodemus flavicollis (Rodentia, Mammalia). Genome Res. 2000;10(1):55-61.
34. Blagojević J, Vujošević M. Do B chromosomes affect morphometric characters in yellow-necked mice Apodemus flavicollis(Rodentia, Mammalia)? Acta Theriol. 2000;45(1):129-38.

Glavni i višegodišnji predmet naših istraživanja je polimorfizam B hromozoma kod žutogrlog miša, Apodemus flavicollis. U cilju rasvetljavanja biološkog smisla ovih dodatnih hromozoma u istraživanjima kombinujemo različite pristupe kao što su analiza hromozoma, geometrijska i tradicionalna morfometrija i brojni molekularni markeri (mikrosateliti, mtDNK, AFLP, RFLP). Pokušavamo da pratimo promene u genetičko-fenotipskoj strukturi u prostoru i vremenu u korelaciji sa karakteristikama životne istorije i demografskom strukturom. Cilj je da objasnimo kako se vrsta nosi sa različitim unutrašnjim i spoljašnjim pritiscima putem lokalnih adaptacija. Preliminarni rezultati koji korelišu B hromozome sa prisustvom endoparazita obećavaju u budućnosti produbljivanje ovih istraživanja. Očekujemo i značajne pomake u rasvetljavanju strukture B hromozoma kod ove vrste koji će teoriju o poreklu B hromozoma podkrepiti konkretnim dokazima.

Sem toga, bavimo se filogenijom i genetičkim diverzitetom različitih vrsta glodara, slepih miševa i zveri. U kontekstu genetičke strukture, kod ispitivanih vrsta prate se prevalenca i intenenzitet dominantnih makro i nekih mikro (virusi) parazita.

Efekti sredinskog zagađenja u vodenim i kopnenim sredinama su takođe predmet našeg interesovanja. Primenjujemo različite testove, koji mere nivoe genotoksičnosti kao što su Allium anafazno-telofazni test, mikronukleus test (na ribama) i in vivo test indukovanih hromozomskih aberacija kod sisara.