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Institute for Biological Research "Siniša Stanković"
National Institute of the Republic of Serbia
University of Belgrade

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Synergistic Effects of Genipin and Alendronate in 3D-Bioprinted Gelatin-Polyvinylpyrrolidone Scaffolds

In this study, we introduce a one-step semi-solid extrusion 3D printing strategy to fabricate gelatin-polyvinylpyrrolidone (GAG-PVP) scaffolds loaded with a low dose (0.5 wt%) of alendronate (ALN) and crosslinked in situ with 1 wt% genipin. The genipin-crosslinked ALN scaffold (GAG-PVP-GEN-ALN) demonstrated enhanced functional performance compared to both non-crosslinked GAG-PVP and GAG-PVP-ALN controls. Its peak swelling reached 462% at 5 h...

Fast Evolving Glioblastoma in a Pregnant Woman: Diagnostic and Therapeutic Challenges

Background and Clinical Significance: Gliomas diagnosed during pregnancy are rare, and there are no established guidelines for their management. Effective treatment requires a multidisciplinary approach to balance maternal health and pregnancy preservation. Case Presentation: We here present a case of rapidly progressing glioma in a 33-year-old pregnant woman. The patient initially presented with a generalized tonic–clonic seizure at 21 weeks’ gestation. Imaging revealed a tumor in the right cerebral lobe, involving both cortical and subcortical structures...

Antioxidant Supplementation with ProCloSupp Protects Against Renal Toxicity of Atypical Antipsychotics in Rats: Implications for Safer Treatment Strategies

Atypical antipsychotics (AAP), including clozapine (Clo), aripiprazole (Ari), and risperidone (Ris), are widely used in psychiatry but can lead to kidney damage due to oxidative stress. This study investigated whether dietary supplementation with selected antioxidants—ellagic acid, vitamin C, zinc, and seleno-methionine (SeMet) in fish oil, formulated as the composite product “ProCloSupp” (PCS)—can mitigate the oxidative...

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