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Institute for Biological Research "Siniša Stanković"
National Institute of the Republic of Serbia
University of Belgrade

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Alteration of hippocampal parvalbumin interneurons underlies memory impairment in rat model of Parkinson’s disease

Cognitive decline is a major non-motor symptom in patients with Parkinson’s disease (PD) that can be present as early as the prodromal stage. As a multisystem neurodegenerative syndrome, PD is associated with disturbances in various neurotransmitters, including dopamine, acetylcholine, serotonin, noradrenaline, glutamate, and gamma-aminobutyric acid (GABA). While the roles of dopaminergic and cholinergic deficiencies in cognitive impairment in PD are well documented...

Enhanced initiation of somatic embryos in suspension cultures of Aesculus flava and metabolic profile of zygotic embryos...

Zygotic embryos (ZEs) of Aesculus species contain a plethora of health-promoting phytochemicals that are used in the pharmaceutical industry and traditional medicine. However, the seed yield decreases due to various stresses, and seeds often contain elevated levels of heavy metals as they are mostly collected from urban environments. Somatic embryos (SEs) could serve as an alternative source of these phytochemicals. Therefore, this study aimed to develop protocols for efficient...

Gene regulatory and co-expression networks reveal novel hub genes and regulatory mechanisms in rapeseed (Brassica napus L.)...

Rapeseed (Brassica napus L.) productivity is increasingly threatened by drought, yet coordinated regulatory programs that govern drought responses remain incompletely characterized. Here, we integrated an RNA-Seq meta-analysis with weighted gene co-expression network analysis (WGCNA) and gene regulatory network (GRN) inference to study in depth the molecular responses of rapeseed to drought stress. WGCNA revealed three modules: brown module...

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