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Institute for Biological Research "Siniša Stanković"
National Institute of the Republic of Serbia
University of Belgrade

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Comparative analysis of in vitro immunomodulatory potential of four Gentiana species

Context: Among Gentiana species present in the Balkan Peninsula, eight are used in traditional medicine mainly for the treatment of gastrointestinal disorders, but other applications have also been recorded, including improving the immune system and health maintenance. Objective: To examine the immunomodulatory potential of methanol extracts obtained from the aerial parts of Gentiana asclepiadea, G. utriculosa, G. cruciata, and G. dinarica. Materials and methods: Following phytochemical analysis of Gentiana extracts by HPLC , splenocytes isolated from Wistar rats...

Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context

Numerous members of the Nepeta genus (family Lamiaceae, subfamily Nepetoideae) are medicinal herbs and sources of important bioactive compounds. Most Nepeta species produce iridoids, which are monoterpenoids that deter herbivores and pathogens and are potential biopesticides. In Nepeta, some species produce iridoid aglycones and glycosylated iridoids (referred to as chemotype A), some produce only glycosylated iridoids (chemotype B), and some produce neither iridoid aglycones nor glycosylated iridoids (chemotype C)...

Cellular-level imaging reveals distinct thallium detoxification strategies in Silene latifolia accessions

The facultative thallium (Tl) hyperaccumulator Silene latifolia can attain the highest known concentrations of Tl of any plant species. This trait is, however, differentiated at the population level with only two known Tl-tolerant and hyperaccumulating accessions occurring at metalliferous sites. This study aimed to reveal the internal dis­tribution of Tl in plant organs and tissues. Silene latifolia subsp. alba from Tl-hyperaccumulating and Tl-sensitive accessions were grown hydroponically under different Tl treatments and analyzed to determine Tl accumulation...

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